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Results for "

GPR119 agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GPR119 (17) Cannabinoid Receptor (1) Cytochrome P450 (1) Dipeptidyl Peptidase (2) GPR84 (1) Potassium Channel (2) TRP Channel (1)
By Research Areas:	Endocrinology (2) Inflammation/Immunology (2) Metabolic Disease (15) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Targets Recommended: GPR119

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155553

GPR119 agonist 2	GPR119	Metabolic Disease
GPR119 agonist 2 (compound 43) is an orally active *GPR119* agonist. GPR119 agonist 2 shows good pharmacokinetic characteristics in rodents and can effectively improve glucose tolerance in mice and rats. GPR119 agonist 2 has the potential to study type 2 diabetes .

HY-12375

BMS-903452

GPR119 Metabolic Disease

BMS-903452 is a potent and selective GPR119 agonist for diabetes research .

BMS-903452	GPR119	Metabolic Disease
BMS-903452 is a potent and selective *GPR119* agonist for diabetes research .

HY-146469

DPP-4/GPR119 modulator 2	Dipeptidyl Peptidase GPR119	Metabolic Disease
DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and *GPR119* agonist with an IC₅₀ of 0.22 μM for DPP-IV and an EC₅₀ of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research . DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146468

DPP-4/GPR119 modulator 1	Dipeptidyl Peptidase GPR119 Potassium Channel	Metabolic Disease
DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and *GPR119* agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC₅₀ of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research . DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108258A

PSN 375963 hydrochloride	GPR119	Endocrinology
PSN 375963 hydrochloride is a potent *GPR119* agonist, with EC₅₀s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 hydrochloride shows similar potency to the endogenous agonist oleoylethanolamide (OEA) .

HY-108258

PSN 375963	GPR119	Endocrinology
PSN 375963 is a potent *GPR119* agonist, with EC₅₀s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA) .

HY-109032

Firuglipel

DS-8500a
GPR119 Metabolic Disease

Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.

Firuglipel DS-8500a	GPR119	Metabolic Disease
Firuglipel (DS-8500a) is an orally available, potent and selective *GPR119* agonist.

HY-12066

GSK1292263 3 Publications Verification	GPR119	Metabolic Disease Inflammation/Immunology
GSK-1292263 is an orally available *GPR119* agonist with pEC₅₀s of 6.9 and 6.7 for human and rat GPR119, respectively. GSK-1292263 can be used for the research of type 2 diabetes mellitus (T2DM) .

HY-15291

MBX-2982

Maximum Cited Publications

9 Publications Verification

GPR119 Metabolic Disease

MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
HY-15566

APD597

1 Publications Verification

JNJ-38431055
GPR119 Metabolic Disease

APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.
HY-18354

GSK1104252A

GPR119 Metabolic Disease

GSK1104252A is a potent and selective GPR119 agonist. GSK1104252A can be used for type 2 diabetes research .

MBX-2982 Maximum Cited Publications 9 Publications Verification	GPR119	Metabolic Disease
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.

APD597 1 Publications Verification JNJ-38431055	GPR119	Metabolic Disease
APD597 is a GPR119 agonist intended for the treatment of type 2 diabetes, with EC50 of 46 nM for hGPR119.

GSK1104252A	GPR119	Metabolic Disease
GSK1104252A is a potent and selective *GPR119* agonist. GSK1104252A can be used for type 2 diabetes research .

HY-W011121

2-Oleoylglycerol	GPR119	Metabolic Disease
2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a *GPR119* agonist, with an EC₅₀ of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo .

HY-16673

PSN632408	GPR119	Metabolic Disease
PSN632408, a selective, orally active *GPR119* agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC₅₀=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication and improve islet graft function. PSN632408 has the potential for the research of obesity and related metabolic disorders .

HY-113653

GSK2041706A GSK706	GPR119	Metabolic Disease
GSK2041706A (GSK706) is a potent G protein-coupled receptor 119 (GPR119) agonist. GSK2041706A can be used for the research of type 2 diabetes .

HY-15564

AR 231453 1 Publications Verification	GPR119	Metabolic Disease
AR 231453 is a potent, specific and orally available *GPR119* agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s .

HY-107535

AS1269574	GPR119 TRP Channel	Metabolic Disease
AS1269574 is a potent, orally available *GPR119* agonist, with an EC₅₀ of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes .

HY-W013788

2-Palmitoylglycerol 2-Palm-Gl	Cannabinoid Receptor	Neurological Disease
2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 .

HY-124571

ZQ-16	GPR84	Inflammation/Immunology
ZQ-16 is a potent and selective GPR84 agonist with an EC₅₀ value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120 .

HY-15565

APD668 1 Publications Verification	GPR119 Cytochrome P450 Potassium Channel	Metabolic Disease
APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC₅₀s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (K_i=0.1 μM). APD668 can be used for the research of steatohepatitis and diabetes .

2-Oleoylglycerol	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	GPR119
2-Oleoylglycerol is a dietary naturally occurring lipid. 2-Oleoylglycerol is a *GPR119* agonist, with an EC₅₀ of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo .

2-Palmitoylglycerol 2-Palm-Gl	Natural Products Microorganisms Source classification Endogenous metabolite	Cannabinoid Receptor
2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 .

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GPR119 agonist

Inhibitors & Agonists

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